<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt37 03PS067MB2 South Africa 2003 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19I, E35D, M36I, R41K, K45R, D60E, Q61E, L63P, H69K, K70R, V82I, L89M, I93L  
>03PS067MB2| codons 1-99
PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEDINLPGKWKPRMIGGIGGFIKVRQYE
EIPIEICGKRAIGTVLVGPTPINIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39E, S48T, K104R, V118I, K122E, D123N, E138A, R172K, K173I, Q174K, T200A, E204K, Q207D, R211K, F214L, V245Q, E248D, A272P, K277R, E291D, V292I, I293V, P313Q, V317A, I326V, Q334C, G335D, R356K, G359T, A371T, T377L, K390R, E399G, A400T, E404D, P420L, V435A, A437V, L452K, V466I, S468P, D471E, T477A, H483Q, L491P, S519N, K527N, K530R, V531I, A534S, A554S  
>03PS067MB2| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKIKNPDIVI
YQYMDDLYVGSDLEIGQHRAKIEKLRDHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTEEAE
LELAENREILKEQVHGAYYDPSKDLVAEIQKQGCDQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLTETVQKIALESIVIWGKTPKFRLPIQKETWGTWWTDYWQATWIPEWEFVNTL
PLVKLWYQLEKEPIAGVETFYVDGAANRETKKGKAGYVTDRGRQKIVPLTETTNQKAELQ
AIQLALQDSGPEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLINKERIYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11D, K14R, S24N, D25E, V31I, M50I, I60V, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, R269K, D278T S283G
>03PS067MB2| codons 1-288
FLDGIDKAQEDHERYHSNWRAMANEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGV
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIKDYGKQMAGTDCVAGRQDED

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006