Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt15 | 03PS026MB1 | South Africa | 2003 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, K14R, I15V, L19I, E35D, M36I, R41K, K43R, H69K, L89M, I93L |
| >03PS026MB1| codons 1-99 PQITLWQRPLVSIRVGGQIKEALLDTGADDTVLEDINLPGKWRPKMIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, T39K, S48T, V60I, T69A, K122E, E169D, K173A, Q174K, D177E, T200A, Q207A, F214L, L228P, V245Q, S268C, A272P, L279I, K281R, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, M357R, G359T, V365I, W383R, K390R, E399D, A400I, E404D, T419A, V435A, L452M, K454R, R461K, V466I, D471E, T477A, H483Q, L491S, S519N, K527N, V531I, A534S, A554K |
| >03PS026MB1| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKEMEKEGKITKIGPENPYNTPI FAIKKKDSAKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRAKNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELRAHLLRWGLTTPDKKHQKEPPFPWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWACQIYPGIKVKQICRLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKRRTA HTNDIKQLTEAVQKIATESIVIRGKTPKFRLPIQKETWDIWWTDYWQATWIPEWEFVNAP PLVKLWYQLEKEPIAGAETFYVDGAANRETKMGRAGYVTDKGRQKIVSLTETTNQKAELQ AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLINKEKIYLSWVPAHK GIGGNEQVDKLVSKGIRKVL |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D6E, E13D, S17N, D25E, V31I, M50I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, N222S, L234I, K240R, A265V, R269K, D278A | S283G |
| >03PS026MB1| codons 1-288 FLDGIEKAQEEHDKYHNNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQSFRVYYRDSRDPIWKGPAR LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQDED |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |