Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6007 | CA64625 | U.S. | 2006 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 157 |
| 2 | 3TC+AZT | 26 |
| 3 | 3TC+AZT+NFV | 48 |
| 4 | D4T+DDI+IDV | 265 |
| 5 | 3TC+ATV+RTV+TDF | 22 |
| 6 | 3TC+ATV+TDF | 131 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I84V, L90M | L10F, L33I, N88D | I13V, Q18H, K20KR, M36MI, N37D, K55R, D60E, I62V, L63P, I66F, A71V, I72T, T91TS |
| >CA64625| codons 1-99 PQITLWQRPFVTVKIGGHLREALLDTGADDTVIEEIDLPGRWKPKLIGGIGGFIRVRQYE QVPIEFCGHKVTGTVLVGPTPVNVIGRDLMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219Q | V35I, T39TAS, K64Y, K122E, I178M, T200TA, D218E, L228H, V245E, A288S, I293V, E297A, K311R, S322T, Q334H, T338S, A355G | Q343QE |
| >CA64626| codons 1-358 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICSEMEKEGKISKIGPENPYNTPV FAIYKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPEQKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVPLTAEAE LELAENREILREPVHGVYYDPTKDLIAEIQKQGHGQWSYQIYEEPFKNLKTGKYGRMR |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |