Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA17599 | CA64053 | U.S. | 2006 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+RTV | 104 |
| 2 | 3TC+D4T+IDV | 130 |
| 3 | 3TC+D4T+LPV | 96 |
| 4 | DDI+EFV+TDF | 38 |
| 5 | APV+DDI+RTV+TDF | 41 |
| 6 | 3TC+AZT+DDI+LPV | 44 |
| 7 | Unknown | 32 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, V82A | L23I, F53L | L10I, I15V, I62V, L63V, H69R, A71V, I72K, L89M, I93L |
| >CA64053| codons 1-99 PQITLWQRPIVTIKVGGQLKEAILDTGADDTVLEEMNLPGRWKPKLIGGIGGLVKVRQYD QVVIEICGRKVKGTVVVGPTPANIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DEKN, M184V, L210W, T215Y | S3SC, V35IT, T39TA, E44ED, S48T, S68SG, K122KE, D123E, D177E, R211KQ, A272P, K277R, I293V |
| >CA64054| codons 1-301 PICPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKDGKITKIGPENPYNTPV FAIKKKNGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWQWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease mutations and protease inhibitor cross resistance. | AAC, 2010 |