Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4360 | CA63983 | U.S. | 2006 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ SQV | 7 |
| 2 | D4T+ DDI+ IDV | 53 |
| 3 | D4T+ DDI+ IDV+ RTV | 57 |
| 4 | D4T+DDI+IDV+RTV+Unknown | 19 |
| 5 | 3TC+ABC+NVP+RTV+SQV | 66 |
| 6 | LPV+NVP+3TC+ABC | 48 |
| 7 | None | 17 |
| 8 | 3TC+LPV+TDF | 5 |
| 9 | Unknown | 196 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73T | T4TA, I15IV, K20KT, E35D, L63P, I64V, A71V, I72L, V77VI, I85V |
| >CA63983| codons 1-99 PQIALWQRPFVTIKVGGQLTEALLDTGADDTVLEDMNLPGRWKPKIIGGIGGFVKVRQYD QIPVEICGHKVLTTVLIGPTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, M184V, L210W, T215Y | D67G, K219E | G190A | V60I, T69N, A98S, K101Q, K122E, D123S, K126KR, I135T, I142V, A158AS, S162A, V179I, G196GR, T200TI, V245E, I293V, E297A | P247PS |
| >CA63984| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKGSNRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLQKKKSVTVLDVGDAYFSVPL DESFRRYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPSIFQASMTKILEPFRKQNPDIII YQYVDDLYVASDLEIRQHRIKIEELRQHLWRWGFYTPDEKHQKEPPFLWMGYELHPDKWT VQPIELSEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTAEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease mutations and protease inhibitor cross resistance. | AAC, 2010 |