Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA14383 | CA63831 | U.S. | 2005 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 313 |
| 2 | DDI | 57 |
| 3 | AZT+DDI | 21 |
| 4 | 3TC+D4T+RTV | 61 |
| 5 | 3TC+D4T+IDV | 82 |
| 6 | 3TC+D4T+NVP+RTV+SQV | 313 |
| 7 | 3TC+ATV+D4T+RTV | 62 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IV, I84V, L90M | L23I, G73S | L10LI, I13L, N37D, L63P, I66IV, C67CF, A71V, I72V, V77I, I93L |
| >CA63831| codons 1-99 PQITLWQRPIVTLKIGGQLKEAILDTGADDTVLEEMDLPGRWKPKIIGGIGGFVKVRQYD QIPIEVFGHKVVSTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215F | V75M, K219W | G190A | K101H | T39N, K43Q, V60I, V118I, D121DH, K122E, I135T, I142V, S162D, K166R, E169ED, G196E, H208FY, R211K, L228H, Q242H, V245E, A272P, L283I, A288S, E297K |
| >CA63832| codons 1-311 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICNELEQEGKISKIGPENPYNTPI FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQDSMTRILDPFRKQNPDIVI YQYVDDLYVASDLEIEQHRTKIEELRQFLWKWGFFTPDWKHQKEPPFHWMGYELHPDKWT VHPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKSLTEVIPLTKEAE LELAENREILK |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease mutations and protease inhibitor cross resistance. | AAC, 2010 |