Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMG98 | 98_w55 | U.K. | 1999 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+NFV | NA |
| 2 | 3TC+AZT | NA |
| 3 | 3TC+AZT+NFV | 10 |
| 4 | None | NA |
| 5 | 3TC+AZT+NFV | 13 |
| 6 | None | NA |
| 7 | 3TC+AZT+NFV | 31 |
| 8 | 3TC+AZT | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K20R, E35D, M36I, N37D, R41K, Q61QE, H69K, I72IV, L89M |
| >98_w55| codons 1-99 PQITLWQRPLVTVKIGGQLREALLDTGADDTVLEDIDLPGKWKPKMIGGIGGFIKVRQYD EILIEICGKKAVGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K11AT, V35T, K46KQ, S48ST, K49R, I50IV, V60I, D121DY, K122E, D123DGNS, I135T, T165TI, E169D, K173A, Q174K, D177E, G196E, Q207A, V245M, A272P, T286A, E291D, I293V, E312D, G335D, M357R, G359S, T369A, A371V, I375V, S379SG |
| >98_w55| codons 1-400 PISPIETVPVTLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGQITRVGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILDPFRAKNPEIVI YQYMDDLYVGSDLEIEQHRTKIEELRAHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDVVPLTEEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARRRSA HTNDVKQLAEVVQKVATEGIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |