<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
DMG96 96_w27 U.K. 1999 HIV1 CRF02_AG Plasma None

Treatment History
Order Regimen Weeks
1 ABC+AZT 27

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, K20R, M36I, N37ND, R41K, H69K, L89M  
>96_w27| codons 1-99
PQITLWQRPLVTVKIGGQLREALLDTGADDTVLEEIDLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6D, V35T, V60I, I135V, S162A, K173A, Q174K, D177E, I178M, T200A, E203D, Q207E, P243H, V245E, K281R, T286A, E291D, V292I, I293V, S322T, G335D, Y339F, R356K, M357K, G359S, T369TA, A371V, I375V, A376S, T377TI, K390R  
>96_w27| codons 1-400
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRAKNPEMVI
YQYMDDLYVGSDLEIGQHRAKIDELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQHIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQDQWTFQIYQEPFKNLKTGKYAKKRSA
HTNDVKQLAEVVQKVSIESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Gibb, DM Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). Antivir Ther, 2002