<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
DMG95 95_w75 U.K. 1999 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ABC+NFV 75

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74V, Y115F, M184V     V179VD V35T, T39E, S48T, V118I, K122E, D123N, E138A, I142V, K173I, Q174K, P176PS, T200E, Q207K, R211K, F214L, V245Q, E248D, K249Q, A272P, K275R, K277R, Q278H, E291D, V292I, I293V, P294E, D324E, I329L, Q334H, G335D, R356K, M357T, G359T, T369A, A376T, T377R, K390R, E396D, T397I  
>95_w75| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSIPL
DENFRKYTAFTIPSINNATPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNSDIDI
YQYVDDLYVGSDLEIGQHREKIEELRKHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDQDSWTVNDIQKLVGKLNWASQIYPGIRVRHLCKLLRGTKALTDIVELTEEAE
LELAENREILKEPVHGVYYDPSKELIAELQKQGHDQWTYQIYQEPFKNLKTGKYAKTRTA
HTNDVKQLAEAVQKITRESIVIWGKTPKFRLPIQKDIWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15V, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, L89M, I93L  
>95_w75| codons 1-99
PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYE
EIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

References
Author Title Citation
Gibb, DM Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). Antivir Ther, 2002