Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMG95 | 95_w75 | U.K. | 1999 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ABC+NFV | 75 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, L89M, I93L |
| >95_w75| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYE EIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, Y115F, M184V | V179VD | V35T, T39E, S48T, V118I, K122E, D123N, E138A, I142V, K173I, Q174K, P176PS, T200E, Q207K, R211K, F214L, V245Q, E248D, K249Q, A272P, K275R, K277R, Q278H, E291D, V292I, I293V, P294E, D324E, I329L, Q334H, G335D, R356K, M357T, G359T, T369A, A376T, T377R, K390R, E396D, T397I |
| >95_w75| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSIPL DENFRKYTAFTIPSINNATPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNSDIDI YQYVDDLYVGSDLEIGQHREKIEELRKHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDQDSWTVNDIQKLVGKLNWASQIYPGIRVRHLCKLLRGTKALTDIVELTEEAE LELAENREILKEPVHGVYYDPSKELIAELQKQGHDQWTYQIYQEPFKNLKTGKYAKTRTA HTNDVKQLAEAVQKITRESIVIWGKTPKFRLPIQKDIWE |
References
| Author | Title | Citation |
| Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |