<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
DMG91 91_w22 U.K. 1998 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 ABC+AZT+NFV 22

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V       E28EA, V35AT, T39E, S48T, W88C, K122E, D123G, T139TK, S162H, K173A, Q174R, D177E, V179I, T200A, Q207AG, R211EK, V245Q, A272PS, V276VA, T286TA, E291D, V292I, I293V, P321S, D324E, Q334H, G335D, R356K, M357R, R358K, G359S, A371AV, T377M, K390R W398W*
>91_w22| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTAEKIKALTEICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNEKPGIRYQYNVLPQGWKGSPAIFQHSMTKILEPFRARNPEIII
YQYVDDLYVGSDLEIGQHRAKIEELRGHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYSGIKAKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDSSKELIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKRKSA
HTNDVKQLTEVVQKIAMESIVIWGKTPKFRLPIQKET*E

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N L10F, N88D, L89V T12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93L  
>91_w22| codons 1-99
PQITLWQRPFVSVKVGGQIKEALLDTGADNTVLEDLELPGRWKPRMIGGIGGFIKVRQYE
QIPIEICGKKAIGTVLVGPTPVNIIGRDVLTQLGCTLNF

References
Author Title Citation
Gibb, DM Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). Antivir Ther, 2002