Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMG90 | 90_w51 | U.K. | 1999 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+NFV | 1 |
| 2 | 3TC+AZT | 51 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | N348NI | K22R, E28A, V35T, K49R, V60I, V106I, K122E, D123N, I135T, I142V, D177E, I178M, I195L, T200I, Q207G, R211K, V245K, A272P, L282C, T286A, I293V, E312EG, S322T, P345Q, F346Y, R356K, M357S, A360T, E370A, T377Q, T386I, K390R, E399D |
| >90_w51| codons 1-399 PISPIETVPVKLKPGMDGPKVRQWPLTAEKIKALTEICTEMEKEGKISRIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYVDDLYVGSDLELGQHRIKIEELRGHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKCLRGAKALTEVVPLTEEAE LELAENREILKGPVHGVYYDPTKDLIAEIQKQGQGQWTYQIYQEQYKILKTGKYAKSRGT HTNDVKQLTAAVQKIAQESIVIWGKIPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L23I | I13V, K20KR, E35D, M36I, R41K, I64V, E65D, V82VI |
| >90_w51| codons 1-99 PQITLWQRPLVTVKIGGQLREAILDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QILVDICGHKAIGTVLVGPTPINIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |