<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
DMG90 90_w51 U.K. 1999 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 3TC+AZT+NFV 1
2 3TC+AZT 51

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  L23I I13V, K20KR, E35D, M36I, R41K, I64V, E65D, V82VI  
>90_w51| codons 1-99
PQITLWQRPLVTVKIGGQLREAILDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QILVDICGHKAIGTVLVGPTPINIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V N348NI     K22R, E28A, V35T, K49R, V60I, V106I, K122E, D123N, I135T, I142V, D177E, I178M, I195L, T200I, Q207G, R211K, V245K, A272P, L282C, T286A, I293V, E312EG, S322T, P345Q, F346Y, R356K, M357S, A360T, E370A, T377Q, T386I, K390R, E399D  
>90_w51| codons 1-399
PISPIETVPVKLKPGMDGPKVRQWPLTAEKIKALTEICTEMEKEGKISRIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL
DENFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI
YQYVDDLYVGSDLELGQHRIKIEELRGHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKCLRGAKALTEVVPLTEEAE
LELAENREILKGPVHGVYYDPTKDLIAEIQKQGQGQWTYQIYQEQYKILKTGKYAKSRGT
HTNDVKQLTAAVQKIAQESIVIWGKIPKFRLPIQKETWD

References
Author Title Citation
Gibb, DM Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). Antivir Ther, 2002