Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMG89 | 89_w21 | U.K. | 1999 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+NFV | 21 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, L33V, N37X, P39PQ, R41K, D60E, L63P, K70KR | N88NK |
| >89_w21| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADDTVVEEMXLQGKWKPKMIGGIGGFIKVRQYE QIPIEICGHRAIGTVLVGPTPVNIIGRKLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, T39K, K43E, K49KR, V60I, D177E, I178M, Q207A, R211K, V245T, D250E, A272Q, Q278H, L282C, T286A, I293V, E297A, A304E, I329L, T338S, P345Q, F346Y, R356K, M357G, A360T, E370A, T377Q, S379C, K390R | E204EDHQ |
| >89_w21| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKEMEEEGKISRIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYMDDLYVGSDLEIGQHRTKIEQLRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPITLPEKESWTVNDIQKLVGKLNWASQIYQGIKVKHLCKCLRGAKALTEVVPLTAEAE LELEENREILKEPVHGVYYDPSKDLIAELQKQGQGQWSYQIYQEQYKNLKTGKYAKGRGT HTNDVKQLTAAVQKIAQECIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |