<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
DMG89 89_w21 U.K. 1999 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 3TC+AZT+NFV 21

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, L33V, N37X, P39PQ, R41K, D60E, L63P, K70KR N88NK
>89_w21| codons 1-99
PQITLWQRPLVTVKIGGQLKEALLDTGADDTVVEEMXLQGKWKPKMIGGIGGFIKVRQYE
QIPIEICGHRAIGTVLVGPTPVNIIGRKLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, T39K, K43E, K49KR, V60I, D177E, I178M, Q207A, R211K, V245T, D250E, A272Q, Q278H, L282C, T286A, I293V, E297A, A304E, I329L, T338S, P345Q, F346Y, R356K, M357G, A360T, E370A, T377Q, S379C, K390R E204EDHQ
>89_w21| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKEMEEEGKISRIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI
YQYMDDLYVGSDLEIGQHRTKIEQLRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPITLPEKESWTVNDIQKLVGKLNWASQIYQGIKVKHLCKCLRGAKALTEVVPLTAEAE
LELEENREILKEPVHGVYYDPSKDLIAELQKQGQGQWSYQIYQEQYKNLKTGKYAKGRGT
HTNDVKQLTAAVQKIAQECIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Gibb, DM Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). Antivir Ther, 2002