<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
DMG86 86_w82 U.K. 1999 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+AZT 17
2 3TC+AZT+NFV 65

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N L10F, N88D, L89V T12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93L  
>86_w82| codons 1-99
PQITLWQRPFVSVKVGGQIKEALLDTGADNTVLEDLELPGRWKPRMIGGIGGFIKVRQYE
QIPIEICGKKAIGTVLVGPTPVNIIGRDVLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V       E28EA, V35AT, T39E, S48T, W88WC, V90VI, K122E, D123G, T139TK, S162H, K173A, Q174R, D177E, V179I, T200A, Q207G, R211K, V245Q, A272S, T286A, E291D, V292I, I293V, P321S, D324E, Q334H, G335D, R356K, M357R, R358K, G359S, A371V, T377M, K390R  
>86_w82| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTAEKIKALTEICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFCEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNEKPGIRYQYNVLPQGWKGSPAIFQHSMTKILEPFRARNPEIII
YQYVDDLYVGSDLEIGQHRAKIEELRGHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDSSKELIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKRKSA
HTNDVKQLTEVVQKIAMESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Gibb, DM Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). Antivir Ther, 2002