Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMG86 | 86_w25 | U.K. | 1998 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 17 |
| 2 | 3TC+AZT+NFV | 8 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K22R, V35T, E40D, D123E, I135L, S162H, K173T, Q174K, I195L, T200A, Q207A, R211K, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294PT, E297A, V317A, S322T, I326V, P345AT, F346Y, R356K, G359S, T377M, S379C |
| >86_w25| codons 1-400 PISPIETVPVKLKPGMDGPKVRQWPLTEEKIKALTEICTDMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQHSMTKILEPFRTKNPDIVI YQYMDDLYVGSDLELGQHRAKIEELRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVTLTAEAE LELAENREILKEPVHGAYYDPTKDLVAEIQKQGQGQWTYQIYQETYKNLKTGKYAKMRSA HTNDVKQLTEAVQKIAMECIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10V, I13V, I15V, G16E, K20KR, E35D, M36I, R41K, R57K, L63T, E65D, I72IATV, L89M |
| >86_w25| codons 1-99 PQITLWQRPVVTVKVEGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD QITIDICGHKAVGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |