Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
DMG86 | 86_w25 | U.K. | 1998 | HIV1 | F | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | 3TC+AZT | 17 |
2 | 3TC+AZT+NFV | 8 |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
L10V, I13V, I15V, G16E, K20KR, E35D, M36I, R41K, R57K, L63T, E65D, I72IATV, L89M |
>86_w25| codons 1-99 PQITLWQRPVVTVKVEGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD QITIDICGHKAVGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
K22R, V35T, E40D, D123E, I135L, S162H, K173T, Q174K, I195L, T200A, Q207A, R211K, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294PT, E297A, V317A, S322T, I326V, P345AT, F346Y, R356K, G359S, T377M, S379C |
>86_w25| codons 1-400 PISPIETVPVKLKPGMDGPKVRQWPLTEEKIKALTEICTDMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQHSMTKILEPFRTKNPDIVI YQYMDDLYVGSDLELGQHRAKIEELRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVTLTAEAE LELAENREILKEPVHGAYYDPTKDLVAEIQKQGQGQWTYQIYQETYKNLKTGKYAKMRSA HTNDVKQLTEAVQKIAMECIVIWGKTPKFKLPIQKETWEA |
References
Author | Title | Citation |
Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |