<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
DMG85 85_w50 U.K. 1999 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ABC 2
2 3TC+ABC+NFV 29
3 None 12
4 3TC+ABC+NFV 7

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V       V35T, E36EA, T39DN, S48T, V60I, K122E, D123S, K166KR, K173A, Q174K, D177E, I178L, G196K, T200A, E204D, Q207KR, R211Q, V245Q, D250E, A272P, K277KR, K281KR, T286TA, E291D, V292I, I293V, Q334DEKN, R356K, G359T, T377M, K390R  
>85_w50| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICNEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRAKNPELVI
YQYVDDLYVGSDLEIKQHRAKIEDLRRHLLQWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNGQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19I, K20KT, E35D, M36I, R41K, L63LV, H69K, V82I, L89M, I93L  
>85_w50| codons 1-99
PQITLWQRPLVSIKVGGQITEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QIVIEICGKKAIGTVLVGPTPINIIGRNMLTQLGCTLNF

References
Author Title Citation
Gibb, DM Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). Antivir Ther, 2002