Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMG85 | 85_w50 | U.K. | 1999 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ABC | 2 |
| 2 | 3TC+ABC+NFV | 29 |
| 3 | None | 12 |
| 4 | 3TC+ABC+NFV | 7 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V35T, E36EA, T39DN, S48T, V60I, K122E, D123S, K166KR, K173A, Q174K, D177E, I178L, G196K, T200A, E204D, Q207KR, R211Q, V245Q, D250E, A272P, K277KR, K281KR, T286TA, E291D, V292I, I293V, Q334DEKN, R356K, G359T, T377M, K390R |
| >85_w50| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICNEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRAKNPELVI YQYVDDLYVGSDLEIKQHRAKIEDLRRHLLQWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNGQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, K20KT, E35D, M36I, R41K, L63LV, H69K, V82I, L89M, I93L |
| >85_w50| codons 1-99 PQITLWQRPLVSIKVGGQITEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QIVIEICGKKAIGTVLVGPTPINIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |