Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMG80 | 80_w32 | U.K. | 1998 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+NFV | 32 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19V, M36I, N37NS, R41K, R57K, L63P, H69K, I72IL, I93L |
| >80_w32| codons 1-99 PQITLWQRPLVSIKVGGQVKEALLDTGADDTVLEEISLPGKWKPKMIGGIGGFIKVKQYD QIPIEICGKKALGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, T39E, A98S, K122E, D123DG, I135R, K173T, D177E, I178IL, T200A, I202V, Q207E, V245Q, A272P, K277R, E291D, V292I, I293V, V317A, Q334HN, G335D, A355AT, R356K, G359T, K366R, K390R |
| >80_w32| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPELVI YQYMDDLYVGSDLEIGQHRAKVEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYTKMRTA HTNDVRQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |