Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMG78 | 78_w9 | U.K. | 1998 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | ABC+AZT+NFV | 9 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30DN, L90LM | L89MV | T12S, I15V, L19I, E35D, M36L, N37E, D60E, L63P, I64IV, H69K, I93L |
| >78_w9| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADNTVLEDLELPGRWKPKMIGGIGGFIKVRQYE QIPVEICGKKAIGTVLVGPTPVNIIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V35AT, T39EK, S48T, W88C, V90VI, K122E, D123G, S162H, K173A, Q174R, D177E, V179VI, T200A, E203ED, Q207AG, R211K, F214FL, V241VI, V245Q, A272PS, T286A, E291D, V292I, I293V, P321S, D324E, Q334H, G335D, N348NT, R356K, M357R, R358K, G359S, A371AV, T377M, K390R |
| >78_w9| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFCEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQHSMTKILEPFRARNPEIII YQYVDDLYVGSDLEIGQHRAKIDELRGHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT IQPIQLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDSSKELIAEIQKQGHDQWTYQIYQEPFKTLKTGKYAKRKSA HTNDVKQLTEVVQKIAMESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |