<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
DMG78 78_w9 U.K. 1998 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 ABC+AZT+NFV 9

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30DN, L90LM L89MV T12S, I15V, L19I, E35D, M36L, N37E, D60E, L63P, I64IV, H69K, I93L  
>78_w9| codons 1-99
PQITLWQRPLVSIKVGGQIKEALLDTGADNTVLEDLELPGRWKPKMIGGIGGFIKVRQYE
QIPVEICGKKAIGTVLVGPTPVNIIGRNVMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V       V35AT, T39EK, S48T, W88C, V90VI, K122E, D123G, S162H, K173A, Q174R, D177E, V179VI, T200A, E203ED, Q207AG, R211K, F214FL, V241VI, V245Q, A272PS, T286A, E291D, V292I, I293V, P321S, D324E, Q334H, G335D, N348NT, R356K, M357R, R358K, G359S, A371AV, T377M, K390R  
>78_w9| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFCEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQHSMTKILEPFRARNPEIII
YQYVDDLYVGSDLEIGQHRAKIDELRGHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
IQPIQLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDSSKELIAEIQKQGHDQWTYQIYQEPFKTLKTGKYAKRKSA
HTNDVKQLTEVVQKIAMESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Gibb, DM Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). Antivir Ther, 2002