Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMG78 | 78_w30 | U.K. | 1999 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | ABC+AZT+NFV | 30 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | E28EA, V35AT, T39E, S48T, W88C, V90VI, K122E, D123G, T139TK, S162H, K173A, Q174R, D177E, V179I, T200A, Q207G, R211K, V245Q, A272PS, T286A, E291D, V292I, I293V, P321S, D324E, Q334H, G335D, R356K, M357R, R358K, G359S, A371AV, T377M, K390R | V276VA |
| >78_w30| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTAEKIKALTEICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFCEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNEKPGIRYQYNVLPQGWKGSPAIFQHSMTKILEPFRARNPEIII YQYVDDLYVGSDLEIGQHRAKIEELRGHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYSGIKAKQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDSSKELIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKRKSA HTNDVKQLTEVVQKIAMESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88ND, L89MV | T12S, I13IV, I15V, L19I, E35D, M36L, N37E, K45KQR, D60E, L63P, H69K, I93L |
| >78_w30| codons 1-99 PQITLWQRPLVSVKVGGQIKEALLDTGADNTVLEDLELPGRWKPRMIGGIGGFIKVRQYE QIPIEICGKKAIGTVLVGPTPVNIIGRDVLTQLGCTLNF |
References
| Author | Title | Citation |
| Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |