<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
DMG68 68_w27 U.K. 1999 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 ABC+AZT+NFV 27

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI   I13V, G16A, K20R, E35D, M36I, R41K, R57K, H69K, L89M  
>68_w27| codons 1-99
PQITLWQRPLVTVKIAGQLREALLDTGADDTVLEDINLPGKWKPKIIGGIGGFIKVKQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V A62V     E6D, K11T, K20R, V35T, K122E, D123N, K173S, D177E, V179I, T200A, I202V, Q207A, V245Q, E248D, T286A, E291D, V292I, I293V, E312N, S322A, I326V, G335D, K353KR, M357K, G359S, K366R, T369A, A371V, K374R, I375V, A376V, T377M  
>68_w27| codons 1-399
PISPIDTVPVTLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV
FVIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSQNPEIII
YQYVDDLYVGSDLEIGQHRAKVEELRAHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKNPVHGVYYDPAKDLVAEIQKQGQDQWTYQIYQEPFKNLKTGRYARKRSA
HTNDVRQLAEVVQRVVMESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Gibb, DM Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). Antivir Ther, 2002