Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMG64 | 64_w26 | U.K. | 1999 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ABC+NFV | 4 |
| 2 | 3TC+ABC | NA |
| 3 | 3TC+ABC+NFV | 22 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | E6EK, V35T, T39A, E40D, W88C, D123E, I135L, S162Y, K173T, Q174K, I178L, I195L, T200A, Q207T, R211K, V245Q, E248N, A272P, A288S, E291D, V292I, I293V, P294T, E297T, I329V, P345T, R356K, G359S, T377M, S379C | Y56YC |
| >64_w26| codons 1-400 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICADMEKEGKISKIGPENPCNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRTKNPDLVI YQYVDDLYVGSDLELGQHRAKIEELRTHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPNKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTDIVTLTTEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQETFKNLKTGKYAKMRSA HTNDVKQLTEAVQKIAMECIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | I15V, G16E, K20R, E35D, M36I, N37NT, R41K, R57K, L63T, E65D, I72T |
| >64_w26| codons 1-99 PQITLWQRPLVTIKVEGQLREALLDTGADNTVLEDITLPGKWKPKMIGGIGGFIKVKQYD QITIDICGHKATGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |