<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
DMG64 64_w26 U.K. 1999 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ABC+NFV 4
2 3TC+ABC NA
3 3TC+ABC+NFV 22

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N   I15V, G16E, K20R, E35D, M36I, N37NT, R41K, R57K, L63T, E65D, I72T  
>64_w26| codons 1-99
PQITLWQRPLVTIKVEGQLREALLDTGADNTVLEDITLPGKWKPKMIGGIGGFIKVKQYD
QITIDICGHKATGTVLVGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V       E6EK, V35T, T39A, E40D, W88C, D123E, I135L, S162Y, K173T, Q174K, I178L, I195L, T200A, Q207T, R211K, V245Q, E248N, A272P, A288S, E291D, V292I, I293V, P294T, E297T, I329V, P345T, R356K, G359S, T377M, S379C Y56YC
>64_w26| codons 1-400
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICADMEKEGKISKIGPENPCNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRTKNPDLVI
YQYVDDLYVGSDLELGQHRAKIEELRTHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPNKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTDIVTLTTEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQETFKNLKTGKYAKMRSA
HTNDVKQLTEAVQKIAMECIVIWGKTPKFKLPIQKETWEA

References
Author Title Citation
Gibb, DM Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). Antivir Ther, 2002