Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMG60 | 60_w50 | U.K. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+NFV | 50 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | L10V, I13V, G16E, E35D, M36I, I62V, L63H |
| >60_w50| codons 1-99 PQITLWQRPVVTVKIEGQLKEALLDTGADNTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | R83K, K122E, D123E, I135T, R211K, A272P, K277R, K281R, T286A, E297K, Q334H, K366R, T369V, A371V, I375V | Q330Q* |
| >60_w50| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEI*KQGHGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVRQLVEVVQKVATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |