<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
DMG59 59_w32 U.K. 1999 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 ABC+AZT+NFV 32

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  L76LF I13V, M36I, R41K, L63S, I64IL, H69K, L89M, I93L  
>59_w32| codons 1-99
PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QISLEICGKKAIGTVFVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V       K20R, V35T, E36A, T39E, K122E, D123G, A158S, K173A, D177E, Q207E, V245Q, A272P, T286A, A288AV, E291D, V292I, I293V, P294T, Q334H, G335D, R356K, M357R, G359T, A371V, I375A, T377L, T386I, K390R Y271YD
>59_w32| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTAICEEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRAQNPEIVI
YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIDPGIKVKQLCKLLRGAKVLTDIVTLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLTEVVQKAALESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Gibb, DM Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). Antivir Ther, 2002