Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMG46 | 46_w48 | U.K. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | ABC+AZT+NFV | 48 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I50IN | L10I, E35D, L63T, I93L |
| >46_w48| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMNLPGRWKPKMIGGNGGFIKVRQYD QITIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V21VI, D123E, D177N, G196E, R211S, A272P, K277R, K281KR, T286A, K287R, P294T, E297R, I329V, Q334E, P345PQ, F346FC, A376S, E399D | K22K* |
| >46_w48| codons 1-399 PISPIETVPVKLKPGMDGPKI*QWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGARALTEVITLTREAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGEGQWTYQIYQEQCKNLKTGKYARMRGA HTNDVKQLTEAVQKISTESIVIWGKTPKFKLPIQKETWD |
References
| Author | Title | Citation |
| Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |