Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMG42 | 42_w42 | U.K. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ABC+NFV | 13 |
| 2 | 3TC+ABC | 29 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, L74LV, Y115YF, M184V | K122E, D123DN, I135K, G196E, V245E, A272P, T286P, E297K, V317A, M357T, A376V |
| >42_w42| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKRKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSVPL DENFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGPKALTEVIPLTKEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKIVTESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K14R, I15V, I62V, L63P, I64IV, H69K, P79D |
| >42_w42| codons 1-99 PQITLWQRPLVTVRVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QVPVEICGKKAIGTVLVGDTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |