Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMG36 | 36_w8 | U.K. | 1998 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, K49KR, K104KR, K122KE, D123DN, S162C, E169D, K173A, Q174K, T200TAIV, Q207AD, R211K, V245Q, E248D, A272P, T286V, E291D, V292I, I293V, E297V, V317VA, I329V, G333E, G359S, T377L, K390R, E399D |
| >36_w8| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRAKNPDIVI YQYMDDLYVGSDLEIGQHRVKIEELRDHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGVKALTDIVPLTVEAE LELAENREILKEPVHGAYYDPSKDLIAEVQKQEQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G17E, E35D, M36I, R57K, Q61N, L63T, E65ED, I72T, L89M |
| >36_w8| codons 1-99 PQITLWQRPLVTIKIGEQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVKQYD NITIDICGHKATGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |