Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMG10 | 10_w56 | U.K. | 1999 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ABC | 57 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, M184V | E6D, K11T, V35T, T39K, K43KQ, D121H, K122E, I142IV, A158S, K173A, D177E, Q207A, R211RK, V245E, D250E, A272P, K275R, V276I, T286TA, E291D, V292I, I293V, P294T, E297K, E312D, G335D, R356K, M357K, G359S, T369A, A371V, I375V, A376T, K390R, K395R |
| >10_w56| codons 1-400 PISPIDTVPVTLKPGMDGPKVKQWPLTEEKIKALTEICKEMEQEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPSIFQSSMTKILEPFRAQNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKESWTVNDIQKLVGKLNWASQIYPGIRIKQLCKLLRGAKALTDIVTLTKEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA HTNDVKQLAEVVQKVTTESIVIWGKTPKFRLPIQRETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K14R, M36I, R41K, H69K, L89M |
| >10_w56| codons 1-99 PQITLWQRPLVTVRIGGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |