<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
DMG10 10_w48 U.K. 1999 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ABC 48

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74V, M184V K219KR     E6D, V8VI, K11T, V35T, T39K, K43KQ, D121H, K122E, A158S, K173A, D177E, D192DN, Q207A, R211RK, V245E, D250E, A272P, K275R, V276I, R284RK, T286TA, E291D, V292I, I293V, P294T, E297K, E312ED, G335D, R356K, M357K, G359S, T369A, A371V, I375V, A376T, K390R, K395R  
>10_w48| codons 1-400
PISPIDTIPVTLKPGMDGPKVKQWPLTEEKIKALTEICKEMEQEGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRAQNPEIVI
YQYVDDLYVGSNLEIGQHRTKIEELRAHLLKWGFTTPDRKHQKEPPFLWMGYELHPDKWT
VQPIELPEKESWTVNDIQKLVGKLNWASQIYPGIRIKQLCKLLKGAKALTDIVTLTKEAE
LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA
HTNDVKQLAEVVQKVTTESIVIWGKTPKFRLPIQRETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, K14R, M36I, R41K, H69K, L89M T31TI
>10_w48| codons 1-99
PQITLWQRPLVTVRIGGQLKEALLDTGADDIVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

References
Author Title Citation
Gibb, DM Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). Antivir Ther, 2002