<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
DMG106 106_w41 U.K. 1999 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 3TC+AZT+NFV 12
2 None NA
3 3TC+AZT+NFV 29

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V A62V     E6D, K11T, K20R, V35T, K122E, D123N, K173S, D177E, V179I, T200A, I202V, Q207A, V245Q, E248D, T286A, E291D, V292VI, I293V, E312N, S322SA, I326V, G335D, M357K, G359S, K366R, T369A, A371V, K374R, I375V, A376V, T377R  
>106_w41| codons 1-399
PISPIDTVPVTLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV
FVIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSQNPEIII
YQYVDDLYVGSDLEIGQHRAKVEELRAHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKNPVHGVYYDPAKDLVAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA
HTNDVRQLAEVVQRVVRESIVIWGKTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L N83D I13V, G16A, K20R, A22V, E35D, M36I, R41K, R57K, I64IV, H69K, L89M  
>106_w41| codons 1-99
PQITLWQRPLVTVKIAGQLREVLLDTGADDTVLEDINLPGKWKPKLIGGIGGFIKVKQYD
QILVEICGKKAIGTVLVGPTPVDIIGRNMLTQIGCTLNF

References
Author Title Citation
Gibb, DM Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). Antivir Ther, 2002