Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMG106 | 106_w41 | U.K. | 1999 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+NFV | 12 |
| 2 | None | NA |
| 3 | 3TC+AZT+NFV | 29 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | A62V | E6D, K11T, K20R, V35T, K122E, D123N, K173S, D177E, V179I, T200A, I202V, Q207A, V245Q, E248D, T286A, E291D, V292VI, I293V, E312N, S322SA, I326V, G335D, M357K, G359S, K366R, T369A, A371V, K374R, I375V, A376V, T377R |
| >106_w41| codons 1-399 PISPIDTVPVTLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSQNPEIII YQYVDDLYVGSDLEIGQHRAKVEELRAHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVPLTEEAE LELAENREILKNPVHGVYYDPAKDLVAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA HTNDVRQLAEVVQRVVRESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L | N83D | I13V, G16A, K20R, A22V, E35D, M36I, R41K, R57K, I64IV, H69K, L89M |
| >106_w41| codons 1-99 PQITLWQRPLVTVKIAGQLREVLLDTGADDTVLEDINLPGKWKPKLIGGIGGFIKVKQYD QILVEICGKKAIGTVLVGPTPVDIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Gibb, DM | Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). | Antivir Ther, 2002 |