<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
DMG104 104_w66 U.K. 1999 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+AZT+NFV 66

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
N88S Q58QE T12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, D60E, Q61E, L63P, H69K, L89M, I93L  
>104_w66| codons 1-99
PQITLWQRPLVSIKVGGQITEALLDTGADDTVLEDINLPGKWKPRMIGGIGGFIKVREYE
EIPIEICGKKAIGTVLVGPTPVNIIGRSMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V       K20R, V35T, E36A, T39E, S48T, V60I, K122E, D123N, E138A, A158S, K173T, Q174K, T200A, Q207E, R211K, V245Q, E248D, D250DE, A272P, K275R, Q278H, K281R, T286A, E291D, V292I, I293V, K311R, Q334DH, G335D, R356K, M357MR, G359T, I375V, T377R, S379C, K390R, E396D, T397V  
>104_w66| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRTKNPDIVI
YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIRVKHLCRLLRGAKALTDIVPLTEEAE
LELAENREILREPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLTEAVQKVARECIVIWGKTPKFRLPIQKDVWE

References
Author Title Citation
Gibb, DM Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). Antivir Ther, 2002