Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1144 | CA60842 | U.S. | 2005 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | DDI | 57 |
| 3 | AZT+DDI | 8 |
| 4 | AZT+DDC | 35 |
| 5 | 3TC+D4T | 13 |
| 6 | AZT+D4T+RTV+SQV | 57 |
| 7 | AZT+D4T+RTV+SQV | 31 |
| 8 | 3TC+D4T+NFV | 17 |
| 9 | 3TC+D4T+NFV+NVP | 52 |
| 10 | 3TC+D4T+NFV+NVP | 26 |
| 11 | 3TC+D4T+IDV+RTV | 233 |
| 12 | 3TC+IDV+RTV+TDF | 24 |
| 13 | 3TC+D4T+IDV+RTV | 59 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, T69D, K70R, M184V, T215F | K219Q | K20KR, A33AG, V35M, V118I, K122E, I135T, S162AD, V179I, I202V, F214L, K223KQ, L228H, E248EK, A272P, K277R, A288AT | I159IL |
| >CA60842| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKGLMEICTELEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPALFQDSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRTKVEELRQHLLRWGLFTPDQKHQQEPPFHWMGYELHPDKWT VQPIVLPKKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKTLTEVIPLTEEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54A, V82AT, L90M | Q58E | L10V, T12TK, L19I, F53Y, D60DE, Q61E, I62V, L63P, A71V, I72V, T74S, V77I, I93L |
| >CA60841| codons 1-99 PQITLWQRPVVKIKIGGQIKEALLDTGADDTVLEEMNLPGRWKPKLIVGIGGYAKVREYE EVPIEICGHKVVGSVLIGPTPTNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |