Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA25675 | CA59626 | U.S. | 2005 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 35 |
| 2 | 3TC+AZT+IDV | 57 |
| 3 | D4T+DDI+NVP | 113 |
| 4 | ABC+IDV+RTV | 87 |
| 5 | 3TC+ABC+AZT+LPV | 217 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | L33F, G73S | L10I, L63P, A71V, V77I, I93L |
| >CA59626| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHKVISTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, M184V, L210W, T215Y | K219N | Y188L | V60I, K64KR, R83K, V118I, K122E, I135T, S162Y, F214FL, L228LH, Q242QH, V245E, T286A |
| >CA59627| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIRKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYVDDLLVGSDLEIGQHRTKIEELRQHLWRWGLYTPDNKHQKEPPFHWMGYELHPDKWT VHPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTEEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease mutations and protease inhibitor cross resistance. | AAC, 2010 |