<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
pt-I ptIW16 U.S. 1996 HIV1 B PBMC MMC

Treatment History
Order Regimen Weeks
1 IDV 16

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, V82A L24I L10H, E35D, N37D, L63P, Q92K  
>ptIW16| 6 | codons 1-99 | clone 6
PQITLWQRPHVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD
QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTKIGCTLNL
>ptIW16| 5 | codons 1-99 | clone 5
PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD
QIPIEICGHKAIGSVLVGPTPANIIGRNLLTQIGCTLNF
>ptIW16| 4 | codons 1-99 | clone 4
PQITLWQRPHVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD
QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTKIGCTLNF
>ptIW16| 3 | codons 1-99 | clone 3
PQITLWQRPHVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD
QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTKIGCTLNF
>ptIW16| 2 | codons 1-99 | clone 2
PQITLWQRPHVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD
QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTKIGCTLNF
>ptIW16| 1 | codons 1-99 | clone 1
PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD
QIPIEICGHKAIGSVLVGPTPANIIGRNLLTQIGCTLNF
>ptIW16| codons 1-99
PQITLWQRPHVTIKIGGQLKEALIDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD
QIPIEICGHKAIGTVLVGPTPANIIGRNLLTKIGCTLNF

References
Author Title Citation
Condra, JH Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor. J Virol, 1996
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005