Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1834 | CA59295 | U.S. | 2005 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 109 |
| 2 | D4T+DDI+RTV | 19 |
| 3 | D4T+DDC+NFV+RTV | 31 |
| 4 | D4T+NFV+RTV | 10 |
| 5 | D4T+IDV+NFV+RTV | 20 |
| 6 | D4T+NFV | 14 |
| 7 | 3TC+D4T+EFV+NFV | 32 |
| 8 | ABC+APV+D4T | 63 |
| 9 | D4T+IDV+NVP+RTV | 27 |
| 10 | AZT+DDI+LPV | 130 |
| 11 | ATV+DDI+NVP | 22 |
| 12 | 3TC+ATV+DDI+RTV+TDF | 69 |
| 13 | DDI+DLV+FPV+FTC+RTV+TDF | 9 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | K101E, Y181C, G190A | V108VI | E28EGKR, T39A, E44D, V118I, D123E, I135T, I178IM, T200A, Q207E, R211K, L228N, P294Q |
| >CA59295| codons 1-304 PISPIETVPVKLKPGMDGPKVKQWPLTREKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI CQYVDDLYVASDLEIGQHRAKIEELREHLWKWGFYTPDKKHQKEPPFNWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIQLTEEAE LELA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L76V, V82A | L10F, L23I, L33F, Q58E | I13V, R57K, D60E, L63P, A71V, I93L |
| >CA59294| codons 1-99 PQITLWQRPFVTVKIGGQLKEAILDTGADDTVFEEMNLPGRWKPKMIGGIGGFVKVKEYE QIPIEICGHKVIGTVVVGPTPANIIGRNLLTQLGCTLNF |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| E138D | S17N, L28I, L45I, L101I, T124A, T125A, F181L |
| >CA124162| codons 1-288 FLDGIDKAQEEHEKYHNNWRAMASDFNIPPVVAKEIVASCDKCQIKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKTIHTDNGSN FTSAAVKAACWWAGIKQDFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV LIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |