Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1443 | CA59286 | U.S. | 2005 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 22 |
| 2 | DDC | 64 |
| 3 | D4T | 30 |
| 4 | D4T+IDV | 6 |
| 5 | 3TC+D4T+IDV | 79 |
| 6 | 3TC+D4T+DLV+NFV+SQV | 55 |
| 7 | 3TC+D4T+NFV+SQV | 196 |
| 8 | 3TC+ABC+APV+D4T+DDI+LPV | 65 |
| 9 | 3TC+ABC+APV+ATV+DDI+RTV+TDF | 22 |
| 10 | 3TC+ABC+APV+ATV+RTV | 48 |
| 11 | 3TC+ABC+ATV+FPV+RTV | 21 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, I54LV, V82A, I84V | L24I, L33F | L10I, I13V, I15IV, L19LV, K43E, D60E, L63P, A71V, I72V |
| >CA59286| codons 1-99 PQITLWQRPIVTVKVGGQVKEALIDTGADDTIFEEMNLPGRWEPKLIGGIGGFVKVRQYE QIPIEICGHKVVGTVLVGPTPANVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K49KR, V60VI, V118I, D123E, I135T, T165TI, D177E, V179I, V245E, A272S, K277R | N136NT |
| >CA59287| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISRIGPENPYNTPI FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTTNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPEIII YQYVDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYSGIKVRQLCKLLRGTKALTEVIPLTEEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease mutations and protease inhibitor cross resistance. | AAC, 2010 |