Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4307 | CA59246 | U.S. | 2005 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 61 |
| 2 | 3TC+D4T+IDV | 35 |
| 3 | DDI+RTV+SQV | 61 |
| 4 | D4T+DDI+RTV+SQV | 44 |
| 5 | 3TC+D4T+IDV+RTV | 13 |
| 6 | 3TC+D4T+IDV+NVP+RTV | 74 |
| 7 | None | 22 |
| 8 | ABC+APV+AZT+DDI+LPV | 52 |
| 9 | 3TC+APV+AZT+DDI+LPV | 31 |
| 10 | 3TC+D4T+LPV+TDF | 65 |
| 11 | 3TC+D4T+RTV+T20+TDF+TPV | 76 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I84V | Q58E | L10V, I13V, I15V, L19I, K20T, M36I, L63P, I64V, Q92K |
| >CA59246| codons 1-99 PQITLWQRPVVTVKVGGQITEALLDTGADDTILEEINLPGRWKPKIVGGIGGFIKVREYD QIPVEICGHKAIGTVLVGPTPVNVIGRNLLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, L210W, T215Y | K103N | V118I, K122E, D177N, I178M, T200A, K277R |
| >CA59247| codons 1-285 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNMVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRG |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease mutations and protease inhibitor cross resistance. | AAC, 2010 |