Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1456 | CA59237 | U.S. | 2005 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC | 30 |
| 2 | AZT+DDC | 43 |
| 3 | 3TC+D4T | 31 |
| 4 | 3TC+AZT | 13 |
| 5 | 3TC+AZT+SQV | 22 |
| 6 | 3TC+AZT+IDV | 65 |
| 7 | 3TC+AZT+NFV | 9 |
| 8 | 3TC+AZT+NVP | 44 |
| 9 | D4T+IDV+RTV | 42 |
| 10 | ABC+APV+D4T+RTV+SQV | 206 |
| 11 | DDI+FTC+RTV+TDF+TPV | 65 |
| 12 | DDI+FTC+LPV+T20+TDF | 52 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219DN | Y188L | V35I, T39A, E44D, V60I, V118I, K122E, I135T, S162C, G196E, T200A, E203K, R211K, K223E, L228HR, A272P, A288AS |
| >CA59237| codons 1-304 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLLVGSDLEIEQHRAKIKELRQHLWKWGFYTPDNKHQEEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVIPLTEEAE LELA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | L33F, F53FL, G73T | L10IV, E35D, M36MI, N37S, K55R, R57RK, L63P, I64V, I66V, A71IV, P79PA, I93IL |
| >CA59236| codons 1-99 PQITLWQRPVVTIKIGGQLKEALLDTGADDTIFEDISLPGRWKPKIVGGIGGLLRVKQYD QIPVEVCGHKVITTVLVGATPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | Genotypic predictors of human immunodeficiency virus type 1 drug resistance. | PNAS, 2006 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |