Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA8049 | CA59208 | U.S. | 2005 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 78 |
| 2 | D4T+DDI+NFV | 135 |
| 3 | D4T+DDI+RTV+SQV | 66 |
| 4 | D4T+DDI+EFV+TDF | 99 |
| 5 | ATV+DDI+RTV+TDF | 75 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I54V, L90M | L33I, N88D | I13V, E35D, M36I, N37T, I62V, L63P, A71T, T74S |
| >CA59208| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVIEDITLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKTIGSVLVGPTPVNIIGRDLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219E | G190E | V35L, K101R, K103R, D177E, I178M, G196E, T200A, E204N, R211K, L228H, V245E, A272P, T286A, E297K |
| >CA59209| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLRKRKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYMDDLYVESDLEIEQHRAKIENLRQHLLKWGFFTPDEKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE L |
References
| Author | Title | Citation |
| Mitsuya, Y | N88D facilitates the co-occurrence of D30N and L90M and the development of multidrug resistance in HIV type 1 protease following nelfinavir treatment failure. | ARHR, 2006 |