Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PL4322 | PL4322 | Portugal | 2003 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+3TC+ABC | 8 |
| 2 | AZT+3TC+ABC | 44 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219Q | V35T, V60I, T69TN, A98S, K122E, D123S, I135L, I167IV, K173A, Q174K, D177E, T200A, Q207QK, R211N, D218E, V245Q, E248D, D250E, A272P, T286A, A288AT, E291D, V292I, I293V, E297A, D324E, I329V, K331N | N54I |
| >PL4322| codons 1-333 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPEIPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKVLEPFRAKNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELRKHLLNWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKTLTDIVPLTAEAE LELAENREILKEPVHGVYYDPSKELIAEVQNQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | I13V, K14R, I15V, K20I, E35D, M36I, R41K, H69K, V82I, L89M |
| >PL4322| codons 1-99 PQITLWQRPLVTVRVGGQLIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPINIIGRNMMTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |