Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PL8822 | 65161 | Portugal | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI+ SQV | 82 |
| 2 | D4T+ 3TC+ NVP+ IDV | 108 |
| 3 | D4T+ DDI+ ABC+ IDV+ LPV | 80 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, L210W, T215Y | K219R | Y181C | V108I, K238N | T7TA, K20R, V35X, K43E, E44D, V60I, K101Q, V118I, K122E, I135L, S162Y, K173A, Q174K, I178L, G196GE, Q197L, E203K, Q207E, R211A, K223Q, L228H, D237DE, V241M, V245Q, E248D, A272P, L283I, T286A, E291D, V292VI, I293V, E297Q, V317A | I37IR |
| >65161| codons 1-335 PISPIEAVPVKLKPGMDGPRVKQWPLTEEKIKALXERCTELEEDGKISKIGPENPYNTPI FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRAKNPDLVI CQYMDDLYVGSDLEIELHRTKIKELREHLWAWGFYTPDRKHQQEPPFHWMGYELHPENWT MQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGAKALTDIVPLTQEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54V, V82A | L24I, F53L | L10I, T12I, I15V, G17E, K20M, E35D, M36IV, N37K, L38M, K43R, R57K, Q61N, L63P |
| >65161| codons 1-99 PQITLWQRPIVIIKVGEQLMEALIDTGADDTVLEDVKMPGRWRPKMIMGIGGLVKVKQYD NIPIEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |