Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PL865 | 105515 | Portugal | 2004 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC+ SQV | 256 |
| 2 | D4T+ 3TC+ SQV | 104 |
| 3 | AZT+ 3TC+ SQV | 126 |
| 4 | D4T+ TDF+ EFV | 53 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L90M | F53L | L10I, I13V, K14KR, K20I, E35D, M36I, N37D, R41K, L63A, H69K, A71V, T74S, V82I, L89I |
| >105515| codons 1-99 PQITLWQRPIVTVRIGGQLIEALLDTGADDTVLEDIDLPGKWKPKMIGGIGGLVKVRQYD QIAIEICGKKVIGSVLVGPTPINIIGRNIMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | K219Q | K103N, Y188FL | A98G | V35T, T39M, E40ED, K43KR, V60I, T69N, K122E, D123S, I135T, K173KR, Q174K, D177E, T200A, E203ED, Q207K, R211S, F214FL, K238KR, V245Q, E248D, D250E, A272P, T286A, V292I, I293V, E297A, E300A, S322ST, D324E, I329V |
| >105515| codons 1-333 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICMDMEREGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRKNPEIVI YQYMDDLLVGSDLEIGQHRAKIDELRKHLLSWGLTTPDQKHQKEPPFLWMGYELHPDRWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIVPLTAEAA LELAENREILKEPVHGVYYDPTKELIAEVQKQG |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |