<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL50521 94398 Portugal 2004 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 D4T+ 3TC 21
2 None 21
3 D4T+ 3TC+ NVP 258

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V, T215F   K103N, M230L   T7A, E28K, K32KE, V35T, T39DEKN, V118VI, D121H, I135T, I142V, S162C, K173A, Q174KR, D177E, G196D, T200A, Q207A, R211K, V245K, T286A, E291D, V292I, I293V, P294T, E297K, A304E, E312D  
>94398| codons 1-334
PISPIEAVPVKLKPGMDGPKVKQWPLTKEKIEALTEICNEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
HKDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRARNPEIVI
YQYVDDLYVGSDLEIDQHRAKIEELRAHLLKWGFFTPDKKHQKEPPFLWLGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTKEAE
LELEENREILKDPVHGVYYDPSKDLIAEIQKQGQ

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, G16E, E35D, M36I, R41K, L63GISV, H69K, L89M, T91V, I93L  
>94398| codons 1-99
PQITLWQRPLVTVKIEGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QIVIEICGKKAIGTVLVGPTPVNIIGRNMLVQLGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005