<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL50488 94311 Portugal 2004 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ 3TC+ NVP 52
2 AZT+ DDI+ NVP 65
3 None 47
4 DDI+ 3TC+ IDV+ RTV 84

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, T215Y   K103N   V35T, K43R, V60I, A98S, K122E, D123S, I135T, K173I, Q174K, D177E, D192DN, T200A, E203D, Q207K, R211N, V245Q, E248D, D250E, A272P, T286A, V292I, I293V, E297T, D320E, D324E, I329V, Q334P  
>94311| codons 1-335
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEREGKISKIGPENPYNTPI
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEIVI
YQYVDDLYVGSNLEIGQHRAKIDELRKHLLNWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIVPLTTEAE
LELAENREILKEPVHGVYYEPSKELIAEVQKQGPG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82T, I84V, L90M   I13V, K14R, I15V, K20I, E35D, M36I, R41K, C67F, H69K, A71V, L89I  
>94311| codons 1-99
PQITLWQRPLVTVRVGGQLIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFVKVRQYD
QILIEIFGKKVIGTVLVGPTPTNVIGRNIMTQIGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005