<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL49657 92049 Portugal 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 DDI+ TDF+ NVP 35
2 AZT+ 3TC+ LPV 8

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R   Y181C   V35T, T39L, E40D, V90VI, D123E, I135IT, S162Y, E169D, K173T, Q174K, Q207D, R211K, V245Q, E248N, A272P, T286A, E291D, V292I, I293V, E297T, I326V, Q334E  
>92049| codons 1-335
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICLDMEKEGKISKIGPENPYNTPV
FAIKRKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILDPFRTKNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRDHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPNKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTTEAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGEG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15V, G17E, K20R, E35D, M36I, R57K, Q61H, L63T, I72T, L89M  
>92049| codons 1-99
PQITLWQRPLVTIKVGEQLREALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVKQYD
HITIEICGHKATGTVLVGPTPVNIIGRNMLTQIGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005