Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PL49657 | 92049 | Portugal | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI+ TDF+ NVP | 35 |
| 2 | AZT+ 3TC+ LPV | 8 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R | Y181C | V35T, T39L, E40D, V90VI, D123E, I135IT, S162Y, E169D, K173T, Q174K, Q207D, R211K, V245Q, E248N, A272P, T286A, E291D, V292I, I293V, E297T, I326V, Q334E |
| >92049| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICLDMEKEGKISKIGPENPYNTPV FAIKRKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILDPFRTKNPDIVI CQYMDDLYVGSDLEIGQHRTKIEELRDHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPNKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTTEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGEG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, G17E, K20R, E35D, M36I, R57K, Q61H, L63T, I72T, L89M |
| >92049| codons 1-99 PQITLWQRPLVTIKVGEQLREALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVKQYD HITIEICGHKATGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |