Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PL48406 | 88662 | Portugal | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ DDI+ EFV | 52 |
| 2 | D4T+ ABC+ APV | 104 |
| 3 | AZT+ 3TC+ ABC | 34 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215F | K219W | Y181C, G190S | V179VF | E28K, K32E, V35T, K49R, V60I, K101Q, K122E, I135V, S162C, E169D, K173A, Q174K, D177E, I178L, Q207D, H208HY, R211K, L228H, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297AT | P52PS |
| >88662| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALTEICTELEKEGKISRIGSENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRAKNPELFI CQYMDDLYVSSDLEIGQHRTKIEELRDYLWKWGFFTPDWKHQKEPPFHWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTTEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I50IV, V82A | L33F | L10I, T12I, I13V, I15IV, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, G68E, I72R, L89M |
| >88662| codons 1-99 PQITLWQRPIVIVKVEGQLREALLDTGADDTVFEDINLPGKWKPKIIGGVGGFIKVKQYD NILIEICEHKARGTVLVGPTPANIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |