Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PL4725 | 100703 | Portugal | 2004 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | 52 |
| 2 | 3TC+D4T+DDI+LPV | 109 |
| 3 | 3TC+APV+LPV+TDF | 50 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML, G48V, I54V, V82S, L90M | V11VI, L33F, Q58E | L10V, I13V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, K70KR, A71T, I72IM, T74S, I85V, L89I, I93L, C95F, T96S |
| >100703| codons 1-99 PQITLWQRPVITVKVGGQIREALLDTGADDTVFEDIDLPGKWKPKLIVGIGGFVRVREYD QVPIEICGKRTMGSVLVGPTPSNIVGRNIMTQLGFSLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219W | K101E, Y181C | A98G, V108I | K20R, E28K, K32E, V35K, T39E, V118I, K122E, D123S, I135T, E138A, K173A, D177G, V179VI, T200A, E203K, L205F, Q207D, H208Y, L210S, R211K, D218E, K223Q, L228H, Q242K, V245Q, K275Q, T286A, E291D, V292I, I293V, Q334E |
| >100703| codons 1-334 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIEALKEICEEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTILDVGDAYFSIPL DESFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPGIII CQYVDDLYVGSDLEIGQHRAKIKEFRDYLSKWGFFTPEWKHQQEPPFHWMGYELHPDKWT VKPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIQVKQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGE |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |