<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL4725 58294 Portugal 2001 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 Unknown 52
2 3TC+D4T+DDI+LPV 4

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82T, L90M Q58E L10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L  
>58294| codons 1-99
PQITLWQRPIVTIKVGGQIREALLDTGADDTVLEDIDLPGKWKPKMIVGIGGFVKVREYD
QVPIEICGKKTIGSVLVGPTPTNIVGRNIMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, T215F K219W K101E, Y181C A98G K20R, K32E, V35K, T39E, S48T, V118I, K122E, D123S, I135T, E138A, K173A, D177G, V179I, T200A, L205F, Q207D, H208Y, L210S, R211K, D218E, K223Q, L228H, Q242K, V245Q, K275Q, T286A, E291D, V292I, I293V  
>58294| codons 1-324
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIEALKEICEEMEKEGKITKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSIPL
DESFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPGIII
CQYMDDLYVGSDLEIGQHRAKIEEFRDYLSKWGFFTPEWKHQQEPPFHWMGYELHPDKWT
VKPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIQVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKD

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005